The Toxicology Department is responsible for the analysis of biological fluids and tissues for the presence or absence of alcohol, drugs, and/or poisons. The department is equipped with a wide array of instrumentation including Headspace Gas Chromatography, Headspace Gas Chromatography/Mass Spectrometry, Enzyme Linked Immunosorbent Assay (ELISA), Liquid Chromatography Quadrupole Time of Flight (LC-QTOF), Gas Chromatography/Mass Spectrometry (GC/MS), and Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS). Additionally, the toxicologists interpret their findings in respect to impairment or toxicity of the compounds detected.
The department primarily handles postmortem and driving under the influence (DUI) investigations. In addition, the department also handles criminal sexual conduct cases, moonshine cases, investigations into potential poisonings and provides emergency analytical services in life or death situations. Rapid preliminary analysis is provided in cases involving child fatalities or officer involved shootings.
Typical toxicological analysis is based on case type and may include:
Analysis for volatiles (i.e. ethanol, methanol, acetone, isopropanol, difluoroethane, isoflurane and toluene)
Preliminary drug screen
Blood
LC-QTOF – For full scope of analysis and thresholds, see attachment below
Urine
ELISA
Amphetamine
Methamphetamine
Benzodiazepines
Cocaine metabolite
Methadone
Tramadol
Zolpidem
Opiates
Oxycodone
Carisoprodol
Marijuana metabolite
Buprenorphine
Dextromethorphan
Barbiturates
Phencyclidine (PCP)
Tricyclic Antidepressants
Fentanyl
General drug screen by GC/MS
General drug screen by LC-MS/MS
Confirmations and quantitations of present compounds where appropriate by GC/MS and LC-MS/MS
Toxicology Department Summary – Capabilities and Services
Analysis of blood, urine, other biological fluids and tissues for:
Ethanol and other volatiles
Drugs – drugs of abuse and other clinically significant drugs
Poisons (i.e. carbon monoxide, arsenic, strychnine, cyanide, pesticides and herbicides)
Analysis of liquids (i.e. moonshine) for ethanol and other volatiles
Consultation and technical assistance in suspected or known poisoning cases
Consultation with coroners, pathologists, investigators or attorneys concerning the results of analysis and interpretation of the toxicological significance of those findings
Expert courtroom testimony in cases providing results of analysis and interpretation of the toxicological significance of those findings
